People with multiple sclerosis (MS) often suffer from cognitive problems. Cognitive problems refer to problems in higher-order brain functioning, such as difficulties to learn and remember information, plan and organize, and to divide attention across multiple tasks. Since cognitive functions are needed during daily activities, such as work, education, and family life, cognitive problems can have a large impact on quality of life. However, the best cognitive treatment options for MS patients are unclear.


The REMIND-MS study aims to increase our knowledge regarding the cause and treatment of cognitive problems among MS patients. We will investigate whether three treatments (mindfulness, cognitive rehabilitation therapy and information by an MS specialist nurse) can reduce the cognitive problems experienced by MS patients. We also aim to investigate the effect of these treatments on mood, daily functioning, well-being, and brain functioning.


Adults with MS between 18 and 65 years old with cognitive complaints (such as forgetfulness, concentration problems), who can speak and read Dutch, and who do not have experience with a mindfulness intervention.


Participants of this study take part in one of the following treatments: (1) mindfulness, (2) cognitive rehabilitation therapy, (3) information by an MS specialist nurse. Participants are randomly allocated to one of these treatments. The treatments take nine weeks and consist of sessions in the VU University Medical Center in Amsterdam or Rehabilitation Center Klimmendaal. In addition, three measurements take place in the VU University Medical Center in Amsterdam. Measurements consist of a neuropsychological examination, a MEG scan (brain scan) and questionnaires.


We are currently recruiting participants. The first treatments will start in the beginning of 2018. More treatment groups will follow at other time points in 2018 and 2019.

By whom

The following centers are involved in this study: the MS Center of the VU University Medical Center in Amsterdam, Rehabilitation Center Klimmendaal in Arnhem, the Center for Mindfulness of the Radboud UMC in Nijmegen, and the Radboud University in Nijmegen.

The principle investigator of this project is dr. Brigit de Jong, neurologist in the VU University Medical Center in Amsterdam. The coordinator of the study is Ilse Nauta, researcher at the VU University Medical Center in Amsterdam.


More information

For more information you can visit the website www.vumc.nl/remindms.nl or contact the study coordinator Ilse Nauta (remindms@vumc.nl).